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Signs of Statin Intolerance

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By Editorial Team

Last Updated:

2 min read

Statins are medicines that help lower cholesterol. They are often prescribed to people to reduce their risk of heart disease and stroke. However, some people experience side effects from statins. This is called statin intolerance.1,2

What is statin intolerance?

Statin intolerance means that a person cannot take statin drugs at a dose needed to lower their cholesterol. This happens because they experience side effects that are too bothersome. These side effects can affect their daily life. It is important to know that not everyone has side effects from statins.2,3

Certain people are more likely to have statin intolerance. Risk factors include:2,3

  • Older age
  • Women
  • Having a smaller body frame
  • Taking multiple medicines which can cause drug interactions
  • Taking a high dose of statins
  • Comorbid conditions such as kidney disease, liver disease, and hypothyroidism

Signs and symptoms of statin intolerance

The most common side effect of statins is muscle pain. This pain can range from mild to severe. It can feel like muscle aches, weakness, or cramping.2,3

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Other symptoms of statin intolerance include:2,3

  • Muscle weakness – You may find it difficult to do everyday activities.
  • Muscle tenderness – Your muscles may be sore to the touch.
  • Fatigue – You may feel very tired.
  • Digestive problems – Some people experience nausea, constipation, or diarrhea.
  • Increased blood sugar – Statins can slightly raise blood sugar levels.
  • Headache, brain fog, and other cognitive effects – Some people report memory problems or confusion, though this is less common.
  • Liver problems – In rare cases, statins can affect liver function. This can be detected through liver enzyme tests.

How are these symptoms treated?

If you experience side effects from statins, talk to your doctor. They may suggest several treatment options, such as:1-3

  • Lowering the dose – Your doctor may reduce the amount of statin you take. This can help reduce side effects.
  • Changing to a different statin – There are several different statin medications. Your doctor may switch you to a different one that you tolerate better.
  • Switching to other cholesterol-lowering drugs – Your doctor may switch you to a non-statin drug to help lower your cholesterol.
  • Taking coenzyme Q10 (CoQ10) supplements – A coenzyme Q10 supplement might help prevent statin side effects.
  • Lifestyle changes – Eating a healthy diet, exercising regularly, limiting alcohol, not smoking, and maintaining a healthy weight can help lower cholesterol.

When to seek medical help

If you experience any of the following symptoms, get medical help immediately, as these could be signs of liver failure:2

  • Unexplained fatigue or weakness
  • Dark urine
  • Yellowing of the skin or eyes
  • Pain in the upper abdomen
  • Loss of appetite

Talk to your doctor

Do not stop taking your statin medicine without talking to your doctor first. Stopping suddenly can be harmful. Your doctor can help you manage your symptoms and find a treatment plan that works for you.1

Remember, statins are important for reducing the risk of heart disease and stroke. If you have any concerns about statin intolerance, talk to your doctor. They can help you make informed decisions about your health.1

Treatment results and side effects can vary from person to person. This treatment information is not meant to replace professional medical advice. Talk to your doctor about what to expect before starting and while taking any treatment.

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